Cell Therapy & Bone Autograft

Stem Cells

Stem cells can differentiate into many different types of cells. There are several types of stem cells, including hematopoietic and mesenchymal. They vary in differentiation potential and the terminal cell types they can become.

Hematopoietic stem cells (HSCs) typically differentiate into blood and vasculature cell components. Mesenchymal stem cells (MSCs) have the capability to differentiate into many different cell types responsible for repair or growth of bone, cartilage, muscle, marrow, tendons, ligaments and connective tissue.

What Is the Composition of Bone Marrow Aspirate (BMA)?

BMA is derived from a patient’s bone marrow. It contains a heterogeneous mix of stem and progenitor cells, platelets and white blood cells—each making their own contribution to the healing process.

The chart below outlines key components of iliac-crest-derived bone marrow.

BMACHipChart_5

Platelets and Growth Factors

Platelets are rich in growth factors, which plays a critical role in the process of stem cell differentiation. Growth factors instruct stem cells to differentiate through proteins, which bind to receptors on the surface of the cell. A signal is delivered to the nucleus to turn off or turn on certain genes, which generates the proteins that dictate cell differentiation.

Why Concentrated BMA?

Concentrated BMA delivers a highly concentrated sample of stem cells, progenitor cells and growth factors directly to the application site, harnessing the body’s biologic potential.

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